Making an impact: what’s new in prehospital emergency care research

Members of the Community and Health Research Unit (CaHRU) recently attended a one-day prehospital emergency care conference in999EMS Cardiff on 27 February 2013 to present studies on behalf of the study teams and being undertaken as part of the Prehospital Emergency Quality and Outcomes (PEQO) programme of research at CaHRU. The conference was sponsored by the Thematic Research Network for Unscheduled and Trauma care (TRUST), Welsh Ambulance Service Trust and the 999 EMS Research Forum.

Viet-Hai Phung presented posters on  “Leadership, innovation and engagement in quality improvement in the Ambulance Services Cardiovascular Quality Initiative: cross sectional study” and “Prehospital outcomes for ambulance service care: systematic review”. Fiona Togher and Viet-Hai Phung presented a poster on “What do users value about the emergency ambulance service?“.

cardiffProfessor Niro Siriwardena presented one of the four oral presentations selected at the conference on the resuslts from the Ambulance Services Cardiovascular Quality Initiative (ASCQI), “The effect of a national ambulance Quality Improvement Collaborative on performance in care bundles for acute myocardial infarction and stroke”. In the afternoon he also conducted a workshop with Dr Steven Macey on “How to include anonymised routine data in emergency care research”.

The conference was a real success and an important opportunity for team members to meet with other leading prehospital researchers in the United Kingdom.

 

 

Trent Regional Society for Academic Primary Care conference

A team from the Community and Health Research Unit recently delivered four oral presentations at the Trent Regional Society for Academic Primary Care conference in Sheffield on 5 March 2013.

Dr Zahid Asghar presented research from the IPVASTIA study funded by the National Institute for Health Research (NIHR) Research for Patient benefit programme on “Influenza vaccination and risk of stroke: self-controlled case-series study” which showed a significant reduction in stroke risk associated with influenza vaccination.

Coral Sirdifield presented an international study involving the University of Lincoln and University of Ghent, Belgium on “General practitioners prescribing of benzodiazepines in Western Primary Care: metasynthesis of qualitative studies”. Jo Middlemass presented work from a recently completed study, Exploring social Networks to Augment Cognitive behavioural Therapy (ENACT) funded by the EPSRC, Patients’ and clinicians’ experiences and perceptions of the primary care management of insomnia: qualitative study.

Finally, Fiona Togher presented preliminary findings from a study, “What do users value about the emergency ambulance service?” sphyg1funded by an NIHR Programme Grant for Applied Health Research, Prehospital Outcomes for Evidence Based Evaluation (PhOEBE).

All four members of the team gave excellent presentations and ably responded to questions. The studies involve a range of programmes of work, including studies on the link between influenza and vascular disease, primary care management of insomnia and prehospital outcome measures, led by Professor Niroshan Siriwardena. The next 2014 Trent Regional Society for Academic Primary Care conference will be held in Lincoln, the first time the University of Lincoln will be hosting the event.

 

 

New study shows that one third of patients with diabetes attended by an ambulance for severe hypoglycaemia transported to hospital

EMAS - A&E 5A new study has been published in Primary Care Diabetes on ‘Severe hypoglycaemia requiring emergency medical assistance by ambulance services in the East Midlands: a retrospective study’. Hypoglycaemia or low blood sugar is important because this may be linked to greater risk of death.

The study involved a new collaboration between the University of Leicester Cardiovascular and Diabetes group (Professors Kamlesh Khunti and Melanie Davies), University of Bristol (Harriet Fisher),  University of Queensland, Australia (Sanjoy Paul),University of Lincoln and East Midlands Ambulance Service NHS Trust (Mohammad Iqbal, Professor Niro Siriwardena).

The study aimed to report the characteristics, treatment and provider costs for people with diabetes requiring an emergency ambulance for severe hypoglycaemia and involved an analysis of routinely collected data on 90,435 emergency calls collected over four months by the East Midlands Ambulance Trust, UK.

There were 523 (0.6%) ambulance attendances for severe hypoglycaemia, with an incidence of 2.76 per 100 patient years: 28% of events occurred at night and 32% of those attended were transported to hospital. Those patients with a higher respiratory rate, indicating difficulty breathing, were more likely to be transported to hospital, whereas patients on treatment with insulin and those with higher blood glucose after treatment of hypoglycaemia were less likely to be transported to hospital.

Median ambulance costs were higher at £176 for individuals not transported to hospital whereas those transported cost £92 reflecting the greater time ambulance staff spent with patients who were enabled to remain at home.

The research team are planning further studies investigating longer term outcomes of prehospital care for hypoglycaemia as part of CaHRU’s Prehospital and Emergency Quality and Outcomes (PEQO) programme.

The impact of New Public Management in the Ambulance Service

The use of performance indicators has been a feature of public policy for over three decades. They were first introduced by the EMAS - PTS 7Conservative Government to tackle perceived inefficiencies in the UK public sector. The answer lay in the New Public Management (NPM) reforms, which imported private sector techniques into the public sector to achieve better value-for-money. Consequently, NPM viewed the relationship between public service providers and users through the prism of a producer-consumer dichotomy, with the emphasis on producing quantifiable outputs. While the NPM reforms were introduced by the Conservatives, they were continued apace by New Labour, who wanted to avoid being too closely-identified with ‘producer’ interests, as Labour had traditionally been.  New Labour, through their emphasis on greater competition and choice, wanted to provide public services that were sensitive to ‘consumer’ needs.

Until April 2011, ambulance service quality has mainly been measured in terms of response times. These response time targets were: for Category A high-emergency calls, 75 per cent of calls to arrive at the scene in less than eight minutes and 95 per cent to arrive within 19 minutes; for serious but not life-threatening Category B calls, an ambulance to arrive within 19 minutes 95 per cent of the time; and Category C calls, which are neither serious nor life-threatening, where the target response time is negotiated locally.

The Category B response time targets were abolished by the Department of Health from 1 April 2011, and a set of Clinical Quality Indicators (CQIs) were introduced to complement the Category A eight-minute response time target. From June 2012, the Category A target was sub-divided into Red 1 and Red 2 calls. The former covers the most time-critical incidents and includes patients with cardiac arrest, breathing difficulties and obstructed airways. Red 2 calls are still serious but less time-critical and include patients suffering from strokes and fits. Some Category B and all existing Category C calls became the new Category C ‘Green calls’, and these were sub-divided into four groups: two serious, but non-threatening and two non-life-threatening groups.

The politically-important Category A eight-minute response time target has focused service delivery priorities on improving outcomes for life-threatening conditions and meets public expectations for a rapid response from the ambulance service. Research evidence suggests that timely interventions significantly improve survival outcomes among patients suffering from Out-of-Hospital Cardiac Arrests (OHCAs), but this condition typically accounts for only 1-2 per cent of the pre-hospital population. Cardiac arrests are part of a ‘first hour quintet’ of conditions, which also includes severe trauma, chest pain, stroke and respiratory distress, where early treatment and shorter pre-hospital times can improve survival outcomes.  Even this quintet of potentially life-threatening conditions only represents 15-20 per cent of pre-hospital calls. Indeed, many ambulance service users do not present with life-threatening conditions at all.

By focusing on such a small proportion of the pre-hospital population, the Category A eight-minute target has led to a number of unintended consequences, not least of which has been the mismatch between resources and patients’ needs. For instance, some ambulance services concentrated vehicles in urban areas, where it was easier to achieve a faster response time, thus creating a potential spatial mismatch between resources and need. There have also been reports of gaming, when staff are under pressure to record the ‘right’ answer, even when response times are longer than eight minutes. Security of tenure for Chief Executives of ambulance services in England depends critically on meeting the eight-minute target, so it was inevitable that resources were channelled into meeting it.[1]  The prioritisation of the Category A target may have led some ambulance services to regard a sub-eight-minute response as a success, even if the patient outcome was poor, and interpreting a response time of more than eight minutes that led to a good patient outcome as a failure.

The target culture in ambulance services may have created tensions between ambulance service managers and frontline clinicians, with diverging priorities between the two. Previous studies have suggested that managers’ key focus may be on meeting external targets while frontline ambulance clinicians are more concerned with delivering high quality care to patients.[2,3] A recent Health Foundation-funded quality improvement project in England, the Ambulance Service Cardiovascular Quality Initiative (ASCQI), which includes a collaboration between East Midlands Ambulance Service NHS Trust, the University of Lincoln, the National Ambulance Research Steering Group and the National Ambulance Services Clinical Quality Group is seeking to investigate the issue of culture in more detail.

The National Institute for Health Research (NIHR)-funded programme for applied health research, Prehospital Outcomes for Evidence-Based Evaluation (PhOEBE), is currently attempting to generate more meaningful measures of prehospital outcomes. The programme aims to achieve this by systematically reviewing the international evidence base relating to prehospital outcomes and linking Hospital Episode Statistics (HES) and Office of National Statistics (ONS) mortality data to risk-adjustment measures of ambulance service care.

While the introduction of CQIs to supplement the response time targets represents progress, there is still an ongoing need to generate a broader range of meaningful outcome measures that better capture the often-complex nature of patients’ experiences of the ambulance service. In generating new quality and outcome measures, there is always a risk of over-complication. Therefore, the new quality and outcome measures need to be sufficiently meaningful without being overly-complex. The PhOEBE programme should make a valuable contribution to this debate.

Viet-Hai Phung, CaHRU

 

1.   Bevan G, Hamblin R. Hitting and missing targets by ambulance services for emergency calls: effects of different systems of performance measurement within the UK. J R Stat Soc Ser A Stat Soc 2009:172: 161-190.

2.   Wankhade P. Performance measurement and the UK emergency ambulance service: Unintended consequences of the ambulance response time targets. International Journal of Public Sector Management 2011:24: 384-402.

3.   Wankhade P. Different cultures of management and their relationships with organizational performance: evidence from the UK ambulance service. Public Money and Management 2012:32: 381-388.

 

How well do newer Z drug sleeping tablets work?

A new study from the CaHRU was published online this December 2012. The full paper is available from the link below:

Huedo-Medina T, Kirsch I, Middlemass J, Klonizakis M, Siriwardena AN.  Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration. British Medical Journal 2012; 345: e8343 doi: 10.1136/bmj.e8343.

BMJ paper

Newer (Z drug or non-benzodiazepine) sleeping tablets are known to have short term benefits for treatment of insomnia but their effectiveness has been questioned because of publication and reporting bias reported in previous meta-analyses. Publication bias is due to positive trials being more likely to be published and reporting bias is where positive results are more likely to be published in papers. The placebo response contributes a large part of the effect of drugs like antidepressants but we know little about the extent of the placebo response to hypnotics.

This review of data submitted to the FDA showed that Z drugs decreased the time to fall asleep both subjectively and measured in a sleep lab. There was little demonstrable effect on other outcomes, partly because most studies tended not to measure these outcomes such as sleep quality, sleep efficiency, waking during the night after going to sleep, although these outcomes are often more important to patients than time to fall asleep.

There is a lot of debate currently about the lack of data from pharmaceutical industry (‘pharma’) trials to undertake independent analyses. The FDA data provide all pharma data prior to drug approval and are a helpful way of independently evaluating drug effects and side effects. Pharma trials tend to be more positive than non-pharma trials so the effects of studies submitted tend to be an overestimate of the effects of the drugs. Most of the pharma trials included in this meta-analysis were of short duration (up to 30 days) and in people with primary insomnia, not linked to depression or pain.

The drugs had more effect with larger doses, which is not surprising, but also had more effect in younger or female patients and regardless of type of drug, which is more surprising.  The drug effect and the placebo response were small and, but the two together produced to a reasonably large response. Around half the effect of the drug was a placebo response, which means the placebo response is important in this type of treatment.

Psychological treatments for insomnia work as well as sleeping tablets in the short term and better in the longer term so focusing on increasing access to these treatments, for example through Resources for Effective Sleep Treatment, would benefit people with sleep problems.